Money Laundering is a big problem of the international economy and only the global common politic can reduce it. States without a money-laundering law contrasting it, or with a soft legislation on this subject, and the possibility to use cash without limits or with high ones, increase and support the money laundering actions. In the world there are some little countries that don't have rules that face this problem, or maybe they have them but they are not suitable. The situation has changed during the last for years as one of these little countries has decided to change its legislation and has developed an anti-money laundering system. This State is Holey See. This paper analyses the anti-money laundering system of the Holey See introduced initially by the Law N. CXXVII/10, later improved with the Law N. CLXVI/12 and finally refined with the Law N. XVIII/13. Especially, it is focused, on two important measures adopted by the Holey See to face the money laundering problem: the theme of the "connected operation" and the limits of the use of the cash in the transactions. To better understand these factors, this paper compares the Holey See measures with the Italian ones issued with the legislation decree N. 231/07.